Have you ever heard about a drug that was developed for one purpose but ultimately showed surprising potential for something else? That’s what happened with Tesofensine.
It was originally meant for treating brain disorders, such as Parkinson’s. Upon experimenting, researchers were surprised by this compound’s ability to cause significant weight loss.
This shifted its goal from mental diseases to obesity treatment. This discovery brought a ray of hope for people struggling to lose weight, despite trying everything, like exercise or dieting.
In this informative article, we will learn about why this compound is generating excitement in the weight loss niche. We will shed light on its history, benefits, dosage, and much more.
Stay tuned till the end to not miss out on anything!
Nitty and Gritty about Tesofensine
Tesofensine has been synthesized in the laboratory. It functions as a triple monoamine reuptake inhibitor, which targets dopamine, norepinephrine, and serotonin. In short, it increases their levels within the brain. The result is suppression of appetite and an increase in energy.
Here’s their properties:
- Molecular Formula: C17H23Cl2NO
- Molecular Weight: 328.3 g/mol
It exhibits high oral bioavailability (~90%) and is mainly metabolized by the liver enzyme CYP3A4. Its half-length is long of approximately 220 hours. Clinical trials have exhibited their efficiency in weight loss.
One of the reliable studies suggests of weight reduction of 9.2% over 24 weeks upon intake of around 0.5 mg daily.
However, its side effects may include:
- Dry Mouth
- Nausea
- Insomnia
- Increased heart rate
Many clinical studies regarding this compound are still ongoing for better clarity of its effectiveness.
History of Tesofensine
The initial development of tesofensine in the 1990s was by the Danish company NeuroSearch. They hoped it would treat neurodegenerative conditions such as Parkinson’s and Alzheimer’s. Researchers found that this compound prevents the reuptake of dopamine, norepinephrine, and serotonin, increasing their presence in the brain.
During the early testing of tesofensine for neurological patients, it was found that many participants lost weight. Therefore, the research focus moved from studying the brain benefits to helping people with excess weight. As a result of this outcome, NeuroSearch studied further to test the SNDRI compound for treating obesity.
Studies and clinical trials, for example, the 2008 trial published in The Lancet, have shown that using tablets leads to a reduction in hunger and notable weight loss. It is still examined and developed under the trade name TPN-101. It is being considered a possible treatment option for obesity.
Here Are Amazing Tesofensine Benefits
Below are the amazing Tesofensine benefits users can experience:
Strongly Suppresses Appetite
Tesofensine increases the levels of dopamine, norepinephrine, and serotonin in the brain while acting as a triple monoamine reuptake inhibitor (SNDRI). These brain chemicals are important in regulating the appetite. Users who use it feel less hungry and can easily control their eating.
Significant Amounts of Weight Loss
24 weeks of testing showed that patients using 0.5 mg of TPN-101 daily on average lost 11.3 kg (25 lbs). It is more than the average weight loss seen with other weight loss drugs. These results prove its usefulness in treating obesity and the health risks associated with it.
Long-Term Effectiveness
Another Tesofensine benefit is its long-term effectiveness. It means there would be fewer chances of rebound weight gain once you stop this medicine. It is due to its prolonged effects on the lateral hypothalamus, which regulates appetite and the feeling of hunger.
Possible Effects on Metabolism
Apart from fat loss, the SNDRI compound indirectly improves insulin sensitivity, cholesterol levels, and blood pressure. This can either prevent or delay type 2 diabetes and heart disease in overweight people.
Convenient Dosing
The last Tesofensine benefit is its slow elimination from the body due to a long half-life. As a consequence, the drug can be taken once a day. This makes it easier for patients to stick to their treatment.
Recommended Tesofensine Dosage for Weight Loss
Clinical trials suggest 0.5 mg once daily as the ideal Tesofensine dosage for weight loss. It perfectly balances between efficiency and tolerability. The results are a surprising reduction in body mass with manageable side effects.
Here is the result of three dosages that were evaluated in the Phase IIb TIPO-1 trial for around 24 weeks:
- 0.25 mg per 24 hours resulted in a fat reduction of 4.5%
- 0.5 mg per 24 hours resulted in a fat reduction of 9.2 %
- 1.0 mg per 24 hours resulted in a fat reduction of 10.6 %
The 0.5 mg Tesofensine dosage almost doubles the body fat loss than existing anti-obesity medications in 2025. And that too with a favorably safe profile. Keep in mind that this compound is still in the investigational phase and not approved for general clinical use. Mentioned dosage recommendations are based on collected clinical trial data.
When to Take Tesofensine
Wondering about Tesofensine, when to take it?
The best time to take it is on an empty stomach in the morning, before breakfast. Ingest it with a full glass of water to ensure proper absorption. Use it at the same time daily for steady levels within your body.
The morning is the ideal time because the medicine will boost the appetite-suppressing effects throughout the day. It can also disturb your sleep if you consume it too late in the day.
Where to Buy Tesofensine
If you’re wondering where to buy Tesofensine, only purchase it from a reputable and research-supported source for the best appetite-suppressant and fat-burning results. The quality of chemicals is key, and not all providers are the same.
The lab-tested, high-purity Tesofensine made for research studies is available at Kimera Chems.
Their highest-quality products are:
- Well-packaged and securely handled when shipped
- Comes with COAs (Certificates of Analysis)
- Delivered quickly, and customers receive support when required.
Anyone doing scientific studies or looking into nootropics should choose this reliable source that puts quality, honesty, and consistency first.
Click on the link to order Tesofensine to get started with your experiments properly:
Closing Up
Tesofensine is an attractive choice for obesity treatment. It can help curb hunger, achieve lasting weight loss, and enhance metabolic health, handling a challenge in several ways.
This compound’s good safety record and convenient dosing encourage many to choose it for effective treatment. Prefer buying from an online trusted supplier, such as the one we mentioned in this article.
While research goes on, it teaches us how science can transform surprising discoveries into important therapies. This dopaminergic slimming agent is a sign of more possibilities for a healthier living.